Dubois B, Hampel H, Feldman HH, et al. Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer’s Association on “The preclinical state of AD”; July 23, 2015; Washington DC, USA. Preclinical
Alzheimer’s disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement. 2016;12(3):292–323. doi: 10.1016/j.jalz.2016.02.002
Elahi F, Miller B. A clinicopathological approach to the diagnosis of dementia. Nat Rev Neurol. 2017 Aug;13(8):457–476. doi: 10.1038/nrneurol.2017.96
Fox N, Petersen R. The G8 Dementia Research Summit – a starter for eight? Lancet. 2013;382(9909):1968–1969. doi: 10.1016/S0140-6736(13)62426–5
Goodman RA, Lochner KA, Thambisetty M, Wingo TS, Posner SF, Ling SM. Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011–2013. Alzheimers Dement. 2017 Jan;13(1):28–37. doi: 10.1016/ j.jalz.2016.04.002. Epub 2016 May 10.
Graff-Radford J. Vascular cognitive impairment. Continuum. 2019 Feb;25(1):147–164. doi: 10.1212/CON.0000000000000684
Hale JM, Schneider DC, Mehta NK, Myrskylä M. Cognitive impairment in the U.S.: lifetime risk, age at onset, and years impaired. SSM Popul Health. 2020;11:100577. doi: 10.1016/j.ssmph.2020.100577. Erratum in: SSM Popul Health. 2020 Dec 10;12:100715.
Imtiaz B, Tolppanen AM, Kivipelto M, Soininen H. Future directions in Alzheimer’s disease from risk factors to prevention. Biochem Pharmacol. 2014;88(4):661–670. doi: 10.1016/j.bcp.2014.01.003. Epub 2014 Jan 10.
Kapasi A, DeCarli C, Schneider JA. Impact of multiple pathologies on the threshold for clinically overt dementia. Acta Neuropathol. 2017;134(2):171–186. doi: 10.1007/s00401-017-1717-7. Epub 2017 May 9.
Katzman R. The prevalence and malignancy of Alzheimer disease: a major killer. Alzheimers Dement. 2008;4(6):378–380. doi: 10.1016/j.jalz.2008.10.003. Epub 2008 Oct 22.
Knopman DS, Petersen RC, Jack CR. A brief history of “Alzheimer disease”: multiple meanings separated by a common name. Neurology, 2019; 92(22):1053–1059. doi: 10.1212/WNL.0000000000007583
Marin-Oto M., Vicente EE, Marin JM. Long term management of obstructive sleep apnea and its comorbidities. Multidiscip Respir Med, 2019;14(1). doi: 10.4081/mrm.2019.24
Meusel L-AC, Greenwood CE, Maione A, Tchistiakova E, MacInstosh BJ, Anderson NC. Cardiovascular risk and encoding-related hippocampal connectivity in older adults. BMC Neurosci, 2019;20(37). doi: 10.1186/s12868-019-0518-4
Neumann MA, Cohn R. Incidence of Alzheimer’s disease in large mental hospital; relation to senile psychosis and psychosis with cerebral arteriosclerosis. Arch Neurol Psychiatry. 1953; 69 (5): 615–636. doi: 10.1001/archneurpsyc.1953.02320290067008
Nowakowski RS. Stable neuron numbers from cradle to grave. Proc Natl Acad Sci 220 For Further Reading USA. 2006;103(33):12219–12220. doi: 10.1073/pnas.0605605103. Epub 2006 Aug 7.
Penke B, Szűcs M, Bogár F. Oligomerization and conformational change turn monomeric β-amyloid and tau proteins toxic: their role in Alzheimer’s pathogenesis. Molecules. 2020; 25. doi: 10.3390/molecules25071659
Rodriguez RD, Grinberg L. Argyrophilic grain disease: an underestimated tauopathy. Dement Neuropsychol. 2015;9:2–8. doi: 10.1590/S1980-57642015 DN91000002
Strassnig M, Ganguli M. About a peculiar disease of the cerebral cortex: Alzheimer’s original case revisited. Psychiatry. 2005;2:30–33.
Volk B. How to keep your brain from shrinking. Life Extension Magazine. https://www.lifeextension.com/magazine/2015/2/combat-age-related-brain-atrophy?utm_source=cj.com&utm_medium=affiliate&utm_campaign=5250933&cjevent=37c6e18e850611eb82fa035f0a240613
Wang H, Li T, Barbarino P, et al. Dementia care during COVID-19. Lancet. 2020; 395(10231):1190–1191. doi: 10.1016/S0140-6736(20)30755-8. Epub 2020 Mar 30.
Yu J-T, Xu W, Tan C–C, et al. Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg. 2020. doi: 10.1136/jnnp-2019-321913
Andersen SL. Centenarians as models of resistance and resilience to Alzheimer’s disease and related dementias. Adv Geriatr Med Res. 2020;2(3):e200018. doi: 10.20900/agmr20200018. Epub 2020 Jul 3.
Boldrini M, Fulmore CA, Tartt AN, et al. Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell. 2018;22(4):589–599.e5. doi: 10.1016/ j.stem.2018.03.015
Boyle PA, Wilson RS, Yu L, et al. Much of late life cognitive decline is not due to common neurodegenerative pathologies. Ann Neurol. 2013;74(3):478–489. doi: 10.1002/ana.23964. Epub 2013 Jul 10.
DeCarli C. Clinically asymptomatic vascular brain injury: a potent cause of cognitive impairment among older individuals. J Alzheimers Dis. 2013;33 Suppl 1(0 1):S417–426. doi: 10.3233/JAD-2012-129004 Exalto LG, Quesenberry CP, Barnes D, Kivipelto M, Biessels GJ, Whitmer RA.
Midlife risk score for the prediction of dementia four decades later. Alzheimers Dement. 2014;10(5):562–570. doi: 10.1016/j.jalz.2013.05.1772. Epub 2013 Sep 10.
Freeze WM, Jacobs HIL, de Jong JJ, et al. White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed. Neurobiol Aging. 2020;85:113–122. doi: 10.1016/j.neurobiolaging.2019.09.017. Epub 2019 Sep 27.
Harrington KD, Schembri A, Lim YY, et al. Estimates of age-related memory decline are inflated by unrecognized Alzheimer’s disease. Neurobiol Aging. 2018;70:170–179. doi: 10.1016/j.neurobiolaging.2018.06.005. Epub 2018 Jun 11.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–1217. doi: 10.1016/j.cell.2013.05.039
Masur DM, Sliwinski M, Lipton RB, Blau AD, Crystal HA. Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons. Neurology.1994;44:1427–1432.
Parikh NS, Kumar S, Rosenblatt R, et al. Association between liver fibrosis and cognition in a nationally representative sample of older adults. Eur J Neurol. 2020; 27 (10): 1895–1903. doi: 10.1111/ene.14384. Epub 2020 Jul 20.
Rogalski EJ. Don’t forget – age is a relevant variable in defining SuperAgers. Alzheimers Dement. 2019;11:560–561. doi: 10.1016/j.dadm.2019.05.008
Rogalski EJ, Gefen T, Shi J, et al. Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project. J Cogn Neurosci. 2013;25(1):29–36. doi: 10.1162/jocn_a_00300
Salthouse TA. Decomposing age correlations on neuropsychological and cognitive variables. J Int Neuropsychol Soc. 2009;15(5):650–661. doi: 10.1017/S1355617709990385. Epub 2009 Jul 2.
Seo SW, Gottesman RF, Clark JM, et al. Nonalcoholic fatty liver disease is associated with cognitive function in adults. Neurology. 2016;86(12):1136–1142. doi: 10.1212/WNL.0000000000002498. Epub 2016 Feb 24.
Sliwinski M, Lipton RB, Buschke H, Stewart W. The effects of preclinical dementia on estimates of normal cognitive functioning in aging. J Gerontol. 1996;51B(4):217–225.
Sorrells SF, Paredes MF, Cebrian-Silla A, et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018; 555 (7696): 377–381. doi: 10.1038/nature25975. Epub 2018 Mar 7. 222 For Further Reading
Vannini P, d’Oliere Uquillasc F, Jacobs HIL, et al. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage Clin. 2019;24. doi: 10.1016/j.nicl.2019.102097
Andersen SL. Centenarians as models of resistance and resilience to Alzheimer’s disease and related dementias. Adv Geriatr Med Res. 2020;2(3):e200018. doi: 10.20900/agmr20200018. Epub 2020 Jul 3.
Arboleda-Velasquez JF, Lopera F, O’Hare M, et al. Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report. Nat Med. 2019;25(11):1680–1683. doi: 10.1038/s41591-019-0611-3. Epub 2019 Nov 4.
Baker BH, Lugo-Candelas C, Wu H, et al. Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder mediated by frontoparietal network brain connectivity. JAMA Pediatr. 2020;174(11):1073–1081. doi: 10.1001/jamapediatrics.2020.3080
Bale TL. Sex matters. Neuropsychopharmacology. 2019;44(1):1–3. doi: 10.1038/s41386-018-0239-x. Epub 2018 Oct 10.
Belloy ME, Napolioni V, Han SS, Le Guen Y, Greicius MD; Alzheimer’s Disease Neuroimaging Initiative. Association of Klotho-VS heterozygosity with risk of Alzheimer disease in individuals who carry APOE4. JAMA Neurol. 2020; 77 (7): 849–862. doi: 10.1001/jamaneurol.2020.0414
Bove R, Secor E, Chibnik LB, et al. Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women. Neurology. 2014;82(3):222–229. doi: 10.1212/WNL.0000000000000033. Epub 2013 Dec 11.
Cairns A, Poulos G, Bogan R. Sex differences in sleep apnea predictors and outcomes from home sleep apnea testing. Nat Sci Sleep. 2016;8:197–205. doi: 10.2147/NSS.S101186
Charkoudian N, Hart ECJ, Barnes JN, Joyner MJ. Autonomic control of body temperature and blood pressure: influences of female sex hormones. Clin Auton Res. 2017;27(3):149–155. doi: 10.1007/s10286-017-0420-z. Epub 2017 May 9.
Chiò A, Brunetti M, Barberis M, et al. The role of APOE in the occurrence of frontotemporal dementia in amyotrophic lateral sclerosis. JAMA Neurol. 2016;73(4):425–430. doi: 10.1001/jamaneurol.2015.4773
Ciudad S, Puig E, Botzanowski T, et al. Aβ(1–42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage. Nature Commun. 2020;11(1), [3014]. doi: 10.1038/s41467-020-16566-1