Lancet 358 (2001), 1129–1133; S. T. Remes et al., “Livestock over Field Crops: Which Factors Explain the Lower Prevalence of Atopy Amongst Farmers’ Children”, Clinical and Experimental Allergy 33 (2003), 427–434.
34 Charlotte Braun-Fahrländer, Erika von Mutius, Allergy and Endotoxin Study Team, “Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children”, New England Journal of Medicine 347 (2002), 869–877.
35 “Dogs over Cats: Childhood Environment and Adult Atopy: Results
from the European Community Respiratory Health Survey”, Journal of Allergy and Clinical Immunology 103 (1999), 415–420; Marco Waser et al., “Exposure to Pets, and the Association with Hay Fever, Asthma, and Atopic Sensitization in Rural Children”, Allergy 60 (2005), 177–184; Erika von Mutius et al., “Exposure to Endotoxin or Other Bacterial Components Might Protect Against the Development of Atopy”, Clinical and Experimental Allergy 30 (2000), 1230–1234.
36 Paolo Matricardi et al., “Exposure to Foodborne and Orofecal Microbes Versus Airborne Viruses in Relation to Atopy and Allergic Asthma: Epidemiological Study”, British Medical Journal 320 (2000), 412–417. Интересно, кстати, что в 2003 году американский иммунолог Дейл Умэцу показал, что гепатит A, возбудитель которого – единственный вирус, для которого была показана связь со снижением заболеваемости аллергиями и астмой, может непосредственно уничтожать T-клетки второго типа, склонные вызывать развитие этих расстройств. Dale Umetsu et al., “Hepatitis A Virus Link to Atopic Disease”, Nature 425 (2003), 576.
37 Dale Umetsu et al., “Functional Heterogeneity Among Human Inducer T Cell Clones”, Journal of Immunology 140 (1988), 4211–4216.
38 Peter Yeung et al., “Heat-Killed Listeria monocytogenes as an Adjuvant Converts Established Murine Th2-Dominated Immune Responses into Th1-Dominated Responses”, Journal of Immunology 151 (1998), 4146–4152.
39 Gesine Hansen et al., “Allergen-Specific Th1 Cells Fail to Counterbalance Th2 Cell-Induced Airway Hyperreactivity but Cause Severe Airway Inflammation”, Journal of Clinical Investigation 103 (1999), 175–183.
40 Philippe Stock et al., “Induction of T Helper Type 1-like Regulatory Cells That Express Foxp3 and Protect Against Airway Hyper-reactivity”, Nature Immunology (2004), 1149–1156.
41 Shohei Hori et al., “Control of Regulatory T Cell Development by the Transcription Factor Foxp3”, Science 299 (2003), 1057–1061.
42 R. S. Wildin et al., “Clinical and Molecular Features of the Immunodysregulation, Polyendocrmopathy, Enteropathy, X Linked (IPEX) Syndrome”, Journal of Medical Genetics 39 (2002), 537–545.
43 Stock et al., “Induction of T Helper Type 1-like Regulatory Cells”.
44 Толл-подобные рецепторы получили такое название вовсе не ради аллюзии на toll booths (будки для сбора денег за проезд по платным дорогам или парковку), а за свое сходство с белком плодовых мушек, который в испорченном состоянии придает им несуразный вид. “Несуразный”по-немецки toll, поэтому Кристиана Нюсляйн-Фольхард (Christiane Nüsslein-Volhard), открывшая эти белки немецкая исследовательница, и дала им такое название.
45 Эта жизненно важная игра в “покажи и расскажи”происходит в основном в лимфатических узлах – этих сгустках специализированной иммунной ткани, в буквальном смысле распухающих от бурной деятельности во время инфекции.
46 R. Maldonado-Lopez et al., “CD8 Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo”, Journal of Experimental Medicine 189 (1999), 587–592.
47 Akiko Iwasaki, Ruslan Medzhitov, “Toll-like Receptor Control of the Adaptive Immune Responses”, Nature Immunology 5 (2004), 987–995.
48 Daniel Hawiger et al., “Dendritic Cells Induce Peripheral T-cell Unresponsiveness Under Steady State Conditions In Vivo”, Journal of Experimental Medicine 194 (2001), 769–779.
49 Ralph Steinman et al., “Tolerogenic Dendritic Cells”, Annual Review of Immunology 21 (2003), 685–711.
50 Ralph Steinman et al., “Dendritic Cells Function In Vivo During the Steady-State: A Role in Peripheral Tolerance”, Annals of the New York Academy of Sciences 987 (2003), 15–27.
51 Stock et al., “Induction of T Helper Type 1-like Regulatory Cells”.
52 Holden Maecker et al., “Vaccination with Allergin-IL-18 Fusion DNA Protects Against, and Reverses Established, Airway Hyperreactivity in a Murine Asthma Model”, Journal of Immunology 166 (2001), 959–965.
53 Braun-Fahrländer et al., “Environmental Exposure to Endotoxin”.
54 Waltraud Eder et al., “Toll-like Receptor 2 as a Major Gene for Asthma in Children of European Farmers”, Journal of Allergy and Clinical Immunology 113 (2004), 482–488.
55 John M. Grange, “Effective Vaccination Against Tuberculosis – A New Ray of Hope”, Clinical and Experimental Immunology 120 (2000), 232–234.
56 Christian Lienhardt, Alimuddin Zumla, “BCG: The Story Continues”, Lancet 366 (2005), 1414–1416.
57 G. M. Bahr et al., “Two Potential Improvements to BCG and Their Effect on Skin Test Reactivity in the Lebanon”, Tubercle 67 (1986), 205–216; John Stanford, “Improving on BCG”, Acta Pathologica, Microbiologica et Immunologica 99 (1991), 103–113.
58 G. D. Prema et al., “A Preliminary Report on the Immunotherapy of Psoriasis”, Indian Medical Gazette 124 (1990), 381–382.
59 G. B. Marks et al., “The Effect of Neonatal BCG Vaccination on Atopy and Asthma at Age 7 to 14 Years: An Historical Cohort Study in a Community with a Very Low Prevalence of Tuberculosis Infection and a High Prevalence of Atopic Disease”, Journal of Allergy and Clinical Immunology 111 (2003), 541–549; C. B. Saanjeevi et al., “BCG Vaccination and GAD65 and IA-2 Autoantibodies in Auto-immune Diabetes in Southern India”, Annals of the New York Academy of Sciences 958 (2002), 293–296; Ramesh Bhonde and Pradeep Prab, “Can We Say Bye to BCG?” Current Science 77 (1999), 1283.
60 A. B. Alexandroff et al., “BCG Immunotherapy of Bladder Cancer: 20 Years On”, Lancet 9165 (1999), 1689–1694.
61 Судя по обзору медицинской литературы по состоянию на 1999 г., использование вакцины Коули обеспечивало уровень коэффициента выживаемости, сравнимый с тем, которого добивались онкологи, лечившие те же разновидности опухолей современными методами. Stephen Hoption Cann et al., “Dr. William Coley and Tumour Regression, a Place in History or in the Future”, Postgraduate Medicine 79 (2003), 672–680.
62 Mary Ann Richardson et al, “Coley Toxins Immunotherapy, a Retrospective Review”, Alternative Therapies in Health and Medicine 5 (1999), 42–47.
63 Аллергия и астма: L. Camporota et al., “Effects of Intradermal Injection of SRL 172 on Allergen-Induced Airway Responses and IL-5 Generation by PBMC in Asthma”, Respiratory and Critical Care Medicine 161 (2000); Peter Arkwright et al., “Intradermal Administration of a Killed Mycobacterium vaccae Suspension (SRL 172) Is Associated with Improvement in Atopic Dermatitis in Children with Moderate-to-Severe Disease”, Journal of Allergy and Clinical Immunology 107 (2001), 531–534; L. Camporota et al., “The Effects of Mycobacterium vaccae on Allergen-Induced Airway Responses in Atopic Asthma”, European Respiratory Journal 21 (2003), 287293. Рак: L. Assersohn et al, “A Randomised Pilot Study of SRL 172 (Mycobacterium vaccae) in Patients with Small Cell Lung Cancer Treated with Chemotherapy”, Clinical Oncology 14 (2002), 23–27; R. Mendes et al., “Clinical and Immunological Assessment of Mycobacterium vaccae (SRL 172) with Chemotherapy in Patients with Malignant Mesethelioma”, British Journal of Cancer 86 (2002), 336–341; S. Nicholson et al., “A Randomized Phase II Trials of SRL 172 (Mycobacterium vaccae) +/– Low-Dose Interleukin-2 in the Treatment of Metastatic Malignant Melanoma”, Melanoma Research 13 (2003), 389–393; A. Maraveyas et al., “Possible Improved Survival of Patients with Stage IV AJCC Melanoma Receiving SRL 172 Immunotherapy: Correlation with Induction of Increased Levels of Intracellular Interleukin-2 in Peripheral Blood Lymphocytes”, Annals of Oncology 10 (1999), 817–824; P. M. Patel et al., “An Evaluation of a Preparation of Mycobacterium vaccae (SRL172) as an Immunotherapeutic Agent in Renal Cancer”, European Journal of Cancer 44 (2008), 216–223.
64 The Dirt Vaccine (документальный фильм, показанный Би-би-си в 2002 г.), серия The Edge Series: Health and Medicine, Eco Services Film; Garry Hamilton, “Let Them Eat Dirt”, New Scientist, July 18, 1998; Susan McCarthy, “Talking Dirty and Bring on the Germs”, salon.com, April 2000.
65 Mary O’Brien et al., “SRL172 (Killed Mycobacterium vaccae) in Addition to Standard Chemotherapy Improves Quality of Life Without Affecting Survival, in Patients with Advanced Non-small-cell Lung Cancer: Phase III Results”, Annals of Oncology 15 (2004), 906–914.
66 John Stanford et al., “Successful Immunotherapy with Mycobacterium vaccae in the Treatment of Adenocarcinoma of the Lung”, European Journal of Cancer 44 (2008), 224–227.
67 11 апреля 2001 г. стоимость акций SR Pharma упала на 76,9 %. Это было самое сильное падение за этот день по данным индекса FTSE 100.
68 National Sweet Itch Centre, “Studies on the Prevention and Treatment of Sweet-Itch”, www.sweet-itch.co.uk/ trials.html.