Carcinogenesis. 2014 Aug; 35 (8): 1872–1880. doi: 10.1093/carcin/bgu120.
128. Kanzaki H, Shinohara F, Itohiya-Kasuya K, Ishikawa M, Nakamura Y. “Nrf2 Activation Attenuates Both Orthodontic Tooth Movement and Relapse.” Journal of Dental Research. Vol. 94, no. 6. (June 2015): 787–794. doi: 10.1177/0022034515577814.
Kanlaya R, Khamchun S, Kapincharanon C, Thongboonkerd V. “Protective Epigallocatechin-3-Gallate (EGCG) via Nrf2 Pathway against Oxalate-Induced Epithelial Mesenchymal Transition (EMT) of Renal Tubular Cells.” Scientific Reports. Vol. 6. (2016): 30233. doi: 10.1038/srep30233.
129. Wang D, Wang Y, Wan X, Yang CS, Zhang J. “Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate Triggered Hepatotoxicity in Mice: Responses of Major Antioxidant Enzymes and the Nrf2 Rescue Pathway.” Toxicology and Applied Pharmacology. Vol. 283, no. 1. (February 15, 2015): 65–74. doi: 10.1016/j.taap.2014.12.018.
130. Ibid.
131. Massini L, Rico D, Martin-Diana A, Barry-Ryan C. “Valorisation of Apple Peels.” European Journal of Food Research & Review. Vol. 3, no. 1. (2013): 1–15. doi: 10.21427/D7R32T.
132. Shoji T, Akazome Y, Kanda T, Ikeda M. “The Toxicology and Safety of Apple Polyphenol Extract.” Food and Chemical Toxicology. Vol. 42, no. 6. (2004): 959–967.
133. Li Y, Guo C, Yang J, Wei J, Xu J, Cheng S. “Evaluation of Antioxidant Properties of Pomegranate Peel Extract in Comparison with Pomegranate Pulp Extract.” Food Chemistry. Vol. 96, no. 2. (2006): 254–260. doi: 10.1016/j.foodchem.2005.02.033.
134. Zhai X. Zhu C, Zhang Y, Sun J, Alim A, Yang X. “Chemical Characteristics, Antioxidant Capacities and Hepatoprotection of Polysaccharides from Pomegranate Peel.” Carbohydrate Polymers. Vol. 202. (December 15, 2018): 461–469. doi: 10.1016/j.carbpol.2018.09.013.
135. Imperatori F, Barlozzari G, Scardigli A, Romani A, Macri G, Polinori N, Bernin R, Santi L. “Leishmanicidal Activity of Green Tea Leaves and Pomegranate Peel Extracts on L. infantum.” Natural Products Research. (June 4, 2018): 1–7. doi: 10.1080/14786419.2018.1481841.
136. Ho CY, Cheng YT, Chau CF, Yen GC. “Effect of Diallyl Sulfide on in Vitro and in Vivo Nrf2-Mediated Pulmonic Antioxidant Enzyme Expression via Activation ERK/p38 Signaling Pathway.” Journal of Agricultural and Food Chemistry. Vol. 60. (2012): 100–107. doi: 10.1021/jf203800d.
137. Colín-González AL, Santana RA, Silva-Islas CA, Chánez-Cárdenas ME, Santamaría A, Maldonado PD. “The Antioxidant Mechanisms Underlying the Aged Garlic Extract and S-Allylcysteine-Induced Protection.” Oxidative Medicine and Cellular Longevity. Vol. 2012, no. 3. (May 2012): 907162. doi: 10.1155/2012/907162.
138. Hsieh TC, Elangovan S, Wu JM. “Differential Suppression of Proliferation in MCF-7 and MDA-MB-231 Breast Cancer Cells Exposed to Alpha-, Gamma– and Delta-Tocotrienols Is Accompanied by Altered Expression of Oxidative Stress Modulatory Enzymes.” Anticancer Research. Vol. 30. (2010): 4169–4176.
139. Sontag TJ, Parker RS. “Influence of Major Structural Features of Tocopherols and Tocotrienols on Their Omega-Oxidation by Tocopherol-Omega-Hydroxylase.” Journal of Lipid Research. Vol. 48, no. 5. (May 2007): 1090–1098.
140. Esatbeyoglu T, Rodriguez-Werner M, Schlösser A, Winterhalter P, Rimbach G. “Fractionation, Enzyme Inhibitory and Cellular Antioxidant Activity of Bioactives from Purple Sweet Potato (Ipomoea Batatas).” Food Chemistry.Vol. 221. (April 15, 2017): 447–456. doi: 10.1016/j.foodchem.2016.10.077.
141. Hwang YP, Choi JH, Choi JM, Chung YC, Jeong HG. “Protective Mechanisms of Anthocyanins from Purple Sweet Potato Against Tert-Butyl HydroperoxideInduced Hepatotoxicity.” Food and Chemical Toxicology. Vol. 49, no. 9. (September 2011): 2081–9. doi: 10.1016/j.fct.2011.05.021.
142. Hwang YP, Choi JH, Yun HJ, Han EH, Kim HG, Kim JY, Park BH, Khanal T, Choi JM, Chung YC, Jeong HG. “Anthocyanins from Purple Sweet Potato Attenuate Dimethylnitrosamine-Induced Liver Injury in Rats by Inducing Nrf2-Mediated Antioxidant Enzymes and Reducing COX-2 and iNOS Expression.” Food and Chemical Toxicology. Vol. 49, no. 1. (January, 2011): 93–9. doi: 10.1016/j.fct.2010.10.002.
143. Wu Q, Wang HD, Zhang X, Yu Q, Li W, Zhou ML, Wang XL.“Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury.” Marine Drugs. Vol. 12, no. 12. (December 2014): 6125–6141. doi: 10.3390/md12126125.
144. Saw CL, Yang AY, Guo Y, Kong AN. “Astaxanthin and Omega-3 Fatty Acids Individually and in Combination Protect Against Oxidative Stress via the Nrf2-ARE Pathway.” Food and Chemical Toxicology. Vol. 62. (December 2013): 869–875. doi: 10.1016/j.fct.2013.10.023.
145. Feng Y, Chu A, Luo Q, Wu M, Shi X, Chen Y. “The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats.” Frontiers in Pharmacology. Vol. 9. (July 2018): 748. doi: 10.3389/fphar.2018.00748.
146. Saito H. “Toxico-Pharmacological Perspective of the Nrf2-Keap1 Defense System against Oxidative Stress in Kidney Diseases.” Biochemical Pharmacology. Vol. 85, no. 7. (April 2013): 865–872. doi: 10.1016/j.bcp.2013.01.006.
147. Pedruzzi LM, Stockler-Pinto MB, Leite M Jr, Mafra D. “Nrf2-keap1 System Versus NF-κB: The Good and the Evil in Chronic Kidney Disease?” Biochimie. Vol. 94, no. 12. (December 2012): 2461–2466. doi: 10.1016/j.biochi.2012.07.015.
148. Loboda A, Rojczyk-Golebiewska E, Bednarczyk-Cwynar B, Lucjusz Z, Jozkowicz A, Dulak J. “Targeting nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives.” Biomolecules & Therapeutics (Seoul). Vol. 20. (2012): 499–505. doi: 10.4062/biomolther.2012.20.6.499.
149. Vomhof-Dekrey EE, Picklo MJ Sr. “The Nrf2-Antioxidant Response Element Pathway: A Target for Regulating Energy Metabolism.” Journal of Nutritional Biochemistry. Vol. 23, no. 10. (October 2012): 1201–1206. doi: 10.1016/j.jnutbio.2012.03.005.
150. Liby KT, Sporn MB. “Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease.” Pharmacological Reviews. Vol. 64, no. 4. (October 2012): 972–1003. doi: 10.1124/pr.111.004846.
151. Jiang XY, Zhu XS, Xu HY, Zhao ZX, Li SY, Li SZ, Cai JH, Cao JM. “Diallyl Trisulfide Suppresses Tumor Growth through the Attenuation of Nrf2/Akt and Activation of p38/JNK and Potentiates Cisplatin Efficacy in Gastric Cancer Treatment.” Acta Pharmacologica Sinica. Vol. 38, no. 7. (July 2017): 1048–1058. doi: 10.1038/aps.2016.176.
152. Yang CM, Huang SM, Liu CL, Hu ML. “Apo-8’-Lycopenal Induces Expression of HO-1 and NQO-1 via the ERK/p38-Nrf2-ARE Pathway in Human HepG2 Cells.” Journal of Agricultural and Food Chemistry. Vol. 60, no. 6. (February 2012): 1576–1585. doi: 10.1021/jf204451n.
153. Linnewiel K, Ernst H, Caris-Veyrat C, Ben-Dor A, Kampf A, Salman H, Danilenko M, Levy J, Sharoni Y. “Structure Activity Relationship of Carotenoid Derivatives in Activation of the Electrophile/Antioxidant Response Element Transcription System.” Free Radical Biology & Medicine. Vol. 47, no. 5. (September 2009): 659–667.
154. Zhang M, Wang S, Mao L, Leak RK, Shi Y, Zhang W, Hu X, Sun B, Cao G, Gao Y, Xu Y, Chen J, Zhang F. “Omega-3 Fatty Acids Protect the Brain against Ischemic Injury by Activating Nrf2 and Upregulating Heme Oxygenase 1.” Journal of Neuroscience. Vol. 34. (2014): 1903–1915. doi: 10.1016/j.freeradbiomed.2009.06.008.
155. Nakagawa F, Morino K, Ugi S, Ishikado A, Kondo K, Sato D, Konno S, Nemoto K, Kusunoki C, Sekine O, Sunagawa A, Kawamura M, Inoue N, Nishio Y, Maegawa H. “4-Hydroxy Hexenal Derived from Dietary n-3 Polyunsaturated Fatty Acids Induces Anti-Oxidative Enzyme Heme Oxygenase-1 in Multiple Organs.” Biochemistry and Biophysical Research Communications. Vol. 43. (2014): 991–996. doi: 10.1016/j.bbrc.2013.12.085.
156. Maher J, Yamamoto M. “The Rise of Antioxidant Signaling – The Evolution and Hormetic Actions of Nrf2.” Toxicology in Applied Pharmacology. Vol. 244, no. 1. (April 2010): 4–15.
157. Ahmadi Z, Ashrafizadeh M. “Melatonin as a Potential Modulator of Nrf2.” Fundamental & Clinical Pharmacology. (July 8, 2019). doi: 10.1111/fcp.12498.
158. Uwitonze AM, Razzaque MS. “Role of Magnesium in Vitamin D Activation and Function.” Journal of the American Osteopathic Association. Vol. 118, no. 3. (March 1, 2018): 181–189. doi: 10.7556/jaoa.2018.037.
159. Houston M. “The Role of Magnesium in Hypertension and Cardiovascular Disease.” Journal of Clinical Hypertension (Greenwich). Vol. 13, no. 11. (November 2011): 843–847. doi: 10.1111/j.1751–7176.2011.00538.x.
160. Bertinato J. “Magnesium Deficiency: Prevalence, Assessment, and Physiological Effects.” Handbook of Famine, Starvation, and Nutrient Deprivation. December 2016. doi: 10.1007/978-3-319-40007-5_6-1.
161. Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. “Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.” Journal of Alzheimer’s Disease. Vol. 49, no. 4. (2016): 971–990.
1. Wall S, Wang ZM, Kendig T, Dobraca D, Lipsett M. “Real-World Cell Phone Radiofrequency Electromagnetic Field Exposures.” Environmental Research. Vol. 171. (April 2019): 581–592. doi: 10.1016/j.envres.2018.09.015.
2. Havas M, Illiatovitch M, Proctor C. “Teacher Student Response to the Removal of Dirty Electricity.” Presented at 3rd International Workshop on the Biological Effects of EMFS, October 4–8, 2004. Kos, Greece. http://electricalpollution.com/documents/WWcolour.pdf.