Обезвредить кислоту. Как нейтрализовать тайного врага вашего здоровья — Дэвид Перлмуттер, Кристин Лоберг

Примечания

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Ниже приведен неполный список книг, статей и онлайн-ресурсов, которые могут быть источником дополнительной информации о ряде идей и концепций, изложенных в книге. Это не исчерпывающий список, но он поможет вам начать с новой точки зрения и жить в соответствии с принципами книги. Многие цитаты взяты из исследований, упомянутых или подробно описанных в тексте. Эти материалы также могут стать основой дальнейших исследований. Если вы не увидите ссылку, упомянутую в книге, посетите сайт DrPerlmutter.com, где вы получите доступ к дополнительным исследованиям и обновляемому списку ссылок.

Peterattiamd.com.

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Здесь и далее автор говорит об уровнях тех или иных показателей во множественном числе, поскольку концентрация в крови меняется много раз в течение дня и замер в конкретное время не отражает всей картины. Прим. пер.

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Centers for Disease Control and Prevention (cdc.gov); American Heart Association (heart.org).

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LUV созвучно английскому слову love (любовь). Прим. пер.

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Выражение автора, означающее, что мочевая кислота разрушает организм, как бомба. Прим. пер.

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Неполный список исследовательских работ доктора Ричарда Джонсона есть на его странице scholar.google.com/citations?user=dTgECeMAAAAJ&hl=en.

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Множество исследований описывают этот феномен; см. Cicerchi Ch. et al. Uric Acid-Dependent Inhibition of AMP Kinase Induces Hepatic Glucose Production in Diabetes and Starvation: Evolutionary Implications of the Uricase Loss in Hominids // FASEB Journal. 2014. August. Vol. 28. № 8. Pp. 3339–3350 // doi.org/10.1096/fj.13-243634. См. также Johnson R. J. et al. Uric Acid, Evolution and Primitive Cultures // Seminars in Nephrology. 2005. January. Vol. 25. № 1. Pp. 3–8 // doi.org/10.1016/j.semnephrol.2004.09.002.

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Обратите внимание, что термины «соль» и «хлорид натрия» часто используются как синонимы, но, строго говоря, хлорид натрия обозначает минерал — один из двух, составляющих соль, кристаллическое вещество, широко применяемое в быту и кулинарии. Если не вдаваться в технические тонкости, то неважно, о чем именно мы говорим — о хлориде натрия или пищевой соли, поскольку в данной книге они обозначают одно и то же. Хлорид натрия — ингредиент соли, который оказывает влияние на организм. Прим. авт.

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В исследовании приводится множество ссылок на литературу большой давности, в этой литературе говорится о причастности фруктозы к гиперурикемии и развитию многих других патологий. Вот некоторые особо ценные: Perheentupa J., Raivio K. Fructose-Induced Hyperuricaemia // The Lancet. 1967. September. Vol. 290. № 7515. Pp. 528–531 // doi.org/10.1016/s0140-6736(67)90494-1; Nakagawa T. et al. A Causal Role for Uric Acid in Fructose-Induced Metabolic Syndrome // American Journal of Physiology — Renal Physiology. 2006. March. Vol. 290. № 3. Pp. F625–F631 // doi.org/10.1152/ajprenal.00140.2005; Robertson S. High Uric Acid Precursor of Obesity, Metabolic Syndrome // News-Medical.Net, September 20, 2012 // news-medical.net/news/20120920/High-uric-acid-precursor-of-obesity-metabolic-syndrome.aspx; Livesey G., Taylor R. Fructose Consumption and Consequences for Glycation, Plasma Triacylglycerol, and Body Weight: Meta-analyses and Metaregression Models of Intervention Studies // American Journal of Clinical Nutrition. 2008. November. Vol. 88. № 5. Pp. 1419–1437; Food Insight. Questions and Answers About Fructose // September 29, 2009 / International Food Information Council Foundation // foodinsight.org/questions-and-answers-about-fructose/; Kuwabara M. et al. Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study // Hypertension. 2017. June. Vol. 69. № 6. Pp. 1036–1044 // doi.org/10.1161/HYPERTENSIONAHA.116.08998; Madero M. et al. The Effect of Two Energy-Restricted Diets, a Low-Fructose Diet Versus a Moderate Natural Fructose Diet, on Weight Loss and Metabolic Syndrome Parameters: A Randomized Controlled Trial // Metabolism. 2011. November. Vol. 60. № 11. Pp. 1551–1559 // doi.org/10.1016/j.metabol.2011.04.001; Choo V. L. et al. Food Sources of Fructose-Containing Sugars and Glycaemic Control: Systematic Review and Meta-analysis of Controlled Intervention Studies // The BMJ. 2018. November. Vol. 363. P. k4644 // doi.org/10.1136/bmj.k4644; Muraki I. et al. Fruit Consumption and Risk of Type 2 Diabetes: Results from Three Prospective Longitudinal Cohort Studies // The BMJ. 2013. August. Vol. 347. P. f5001 // doi.org/10.1136/bmj.f5001; Dhingra R. et al. Soft Drink Consumption and Risk of Developing Cardiometabolic Risk Factors and the Metabolic Syndrome in Middle-Aged Adults in the Community // Circulation. 2007. July. Vol. 116. № 5. Pp. 480–488 // doi.org/10.1161/CIRCULATIONAHA.107.689935; Semnani-Azad Zh. et al. Association of Major Food Sources of Fructose-Containing Sugars with Incident Metabolic Syndrome: A Systematic Review and Meta-analysis // JAMA Network Open. 2020. July. Vol. 3. № 7. P. e209993 // doi.org/10.1001/jamanetworkopen.2020.9993; Nseir W., Nassar F., Assy N. Soft Drinks Consumption and Nonalcoholic Fatty Liver Disease // World Journal of Gastroenterology. 2010. June. Vol. 16. № 21. Pp. 2579–2588 // doi.org/10.3748/wjg.v16.i21.2579; Soleimani M., Alborzi P. The Role of Salt in the Pathogenesis of Fructose-Induced Hypertension // International Journal of Nephrology. 2011. Article ID 392708 // doi.org/10.4061/2011/392708; DiNicolantonio J. J., Lucan S. C. The Wrong White Crystals: Not Salt but Sugar as Aetiological in Hypertension and Cardiometabolic Disease // Open Heart. 2014. November. Vol. 1. № 1. P. e000167 // doi.org/10.1136/openhrt-2014-000167; Purnell J. Q. et al. Brain Functional Magnetic Resonance Imaging Response to Glucose and Fructose Infusions in Humans // Diabetes, Obesity and Metabolism. 2011. March. Vol. 13. № 3. Pp. 229–234 // doi.org/10.1111/j.1463–1326.2010.01340.x.

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Я накопил множество исследований о влиянии фруктозы на организм. Вот несколько из них для начала: Stanhope K. L. et al. Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL–Cholesterol, and Apolipoprotein-B in Young Men and Women // Journal of Clinical Endocrinology and Metabolism. 2011. October. Vol. 96. № 10. Pp. E1596–E1605 // doi.org/10.1210/jc.2011–1251; Della Corte K. W. et al. Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-analysis of Intervention Studies // Nutrients. 2018. May. Vol. 10. № 5. P. 606 // doi.org/10.3390/nu10050606; Rezvani R. et al. Effects of Sugar-Sweetened Beverages on Plasma Acylation Stimulating Protein, Leptin and Adiponectin: Relationships with Metabolic Outcomes // Obesity. 2013. December. Vol. 21. № 12. Pp. 2471–2480 // doi.org/10.1002/oby.20437; Ouyang X. et al. Fructose Consumption as a Risk Factor for Non-alcoholic Fatty Liver Disease // Journal of Hepatology. 2008. June. Vol. 48. № 6. Pp. 993–999 // doi.org/10.1016/j.jhep.2008.02.011; Elliott S. S. et al. Fructose, Weight Gain, and the Insulin Resistance Syndrome // American Journal of Clinical Nutrition. 2002. November. Vol. 76. № 5. Pp. 911–922 // doi.org/10.1093/ajcn/76.5.911; Ndrepepa G. Uric Acid and Cardiovascular Disease // Clinica Chimica Acta. 2018. September. Vol. 484. Pp. 150–163 // doi.org/10.1016/j.cca.2018.05.046; Abid A. et al. Soft Drink Consumption Is Associated with Fatty Liver Disease Independent of Metabolic Syndrome // Journal of Hepatology. 2009. November. Vol. 51. № 5. Pp. 918–924 // doi.org/10.1016/j.jhep.2009.05.033; Kelishadi R., Mansourian M., Heidari-Beni M. Association of Fructose Consumption and Components of Metabolic Syndrome in Human Studies: A Systematic Review and Meta-analysis // Nutrition. 2014. May. Vol. 30. № 5. Pp. 503–510 // doi.org/10.1016/j.nut.2013.08.014; Glushakova O. et al. Fructose Induces the Inflammatory Molecule ICAM-1 in Endothelial Cells // Journal of the American Society of Nephrology. 2008. September. Vol. 19. № 9. Pp. 1712–1720 // doi.org/10.1681/ASN.2007121304; Khitan Z., Kim D. H. Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension // Journal of Nutrition and Metabolism. 2013. Article ID 682673 // doi.org/10.1155/2013/682673; Johnson R. J. et al. Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes? // Endocrine Reviews. 2009. February. Vol. 30. № 1. Pp. 96–116 // doi.org/10.1210/er.2008–0033; Johnson R. J. et al. Potential Role of Sugar (Fructose) in the Epidemic of Hypertension, Obesity and the Metabolic Syndrome, Diabetes, Kidney Disease, and Cardiovascular Disease // American Journal of Clinical Nutrition. 2007. October. Vol. 86. № 4. Pp. 899–906; Lanaspa M. A. et al. Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress: Potential Role in Fructose-Dependent and Independent Fatty Liver // Journal of Biological Chemistry. 2012. November. Vol. 287. № 48. Pp. 40732–40744 // doi.org/10.1074/jbc.M112.399899; Rho Y. H., Zhu Y., Choi H. K. The Epidemiology of Uric Acid and Fructose // Seminars in Nephrology. 2011. September. Vol. 31. № 5. Pp. 410–419 // doi.org/10.1016/j.semnephrol.2011.08.004; Johnson R. J. et al. Sugar, Uric Acid, and the Etiology of Diabetes and Obesity // Diabetes. 2013. October. Vol. 62. № 10. Pp. 3307–3315 // doi.org/10.2337/db12-1814.

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Последние исследования не подтверждают значимого снижения уровня мочевой кислоты у больных подагрой при использовании витамина С. При этом суточная потребность в этом витамине 90 мг. Более высокие дозы могут вызывать побочные эффекты. Прим. науч. ред.

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Если вы хотите получить больше информации от доктора Кейси Минc и вводный курс по непрерывному мониторингу глюкозы, предлагаю вам послушать интервью с ней в моем подкасте на сайте: drperlmutter.com/continuous-glucose-monitoring-a-powerful-tool-for-metabolic-health/.

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В России оборудование для непрерывного мониторинга глюкозы можно найти в магазинах медицинских и диабетических товаров. Прим. пер.

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См. интервью с доктором Кейси Минc в моем подкасте от 1 июня 2021 г.: drperlmutter.com/continuous-glucose-monitoring-a-powerful-tool-for-metabolic-health/.

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Панда С. Циркадный код: Как настроить свои биологические часы на здоровую жизнь. Минск: Попурри, 2019. Прим. ред.

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В России можно найти в продаже глюкометры с расширенными функциями, которые позволяют проверить не только глюкозу в крови, но и мочевую кислоту, холестерин и т. д. Прим. пер.

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Рекомендуемая суточная норма потребления для витамина С — 90 мг. Прим. ред.

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Вот для начала небольшая подборка исследований меда: Al-Waili N. et al. Honey and Cardiovascular Risk Factors, in Normal Individuals and in Patients with Diabetes Mellitus or Dyslipidemia // Journal of Medicinal Food. 2013. December. Vol. 16. № 12. Pp. 1063–1078 // doi.org/10.1089/jmf.2012.0285; Zuliani Ramli N. et al. A Review on the Protective Effects of Honey Against Metabolic Syndrome // Nutrients. 2018. August. Vol. 10. № 8. P. 1009 // doi.org/10.3390/nu10081009; Erejuwa O. O., Sulaiman S. A., Ab Wahab M. S. Honey — A Novel Antidiabetic Agent // International Journal of Biological Sciences. 2012. Vol. 8. № 6. Pp. 913–934 // doi.org/10.7150/ijbs.3697.

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Колд брю — метод заваривания кофе грубого помола холодной чистой водой; напиток настаивается в течение 8–24 часов. Прим. ред.

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