Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated Within 6 Months of Disease Onset. Ophthalmology 128, no. 5 (2021): 649-60.
1 Solomon A. Far from the Tree: Parents, Children and the Search for Identity. New York: Scribner, 2013. [Соломон Э. Далеко от яблони. М.: ACT, 2022.]
2 Monod J. Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology. New York: Alfred A. Knopf, 1971.
3 Paweletz N. Walther Flemming: Pioneer of Mitosis Research. Nature Reviews Molecular Cell Biology 2, no. 1 (2001): 72-5.
4 Flemming W. Contributions to the Knowledge of the Cell and Its Vital Processes: Part 2. Journal of Cell Biology 25, no. 1 (1965): 1-69.
5 Там же.
6 The p 53 Tumor Suppressor Protein // Genes and Disease. Bethesda, MD: National Center for Biotechnology Information, 2021.
7 Из беседы с Полом Нёрсом в марте 2017 года; Sir Paul Nurse:
I Looked at My Birth Certificate. That Was Not My Mother s Name. Guardian (International edition), 2014.
8 Hunt T. Biographical. Nobelprize.org.
9 Hunt T. Protein Synthesis, Proteolysis, and Cell Cycle Transitions. Nobel Lecture, Stockholm, December 9, 2021.
10 Из беседы с Полом Нёрсом в марте 2017 года.
11 Lavietes S. Dr. L. В. Shettles, 93, Pioneer in Human Fertility. New York Times, 2003. Подробности эксперимента Шеттлса: Fowled ge T. M. A Report from the Del Zio Trial. Hastings Center Report 8, no. 5 (1978): 15-7.
12 Test Tube Babies: Landrum Shettles. PBS American Experience, 2022. Подробнее о работе Эдвардса и Стептоу: Johnson М. Н. Robert Edwards: The Path to IVF. Reproductive Biomedicine Online
23, no. 2 (2011): 245-62; см. также: Fanu J. L. The Rise and Fall of Modern Medicine. New York: Carroll & Graf, 2000.
13 Edwards R. G., Steptoe P. C. A Matter of Life: The Story of a Medical Breakthrough. New York: William Morrow, 1980.
14 Rock J., Menkin M. F. In Vitro Fertilization and Cleavage of Human Ovarian Eggs. Science 100, no. 2588 (1944): 105-7.
15 Chang M. C. Fertilizing Capacity of Spermatozoa Deposited into the Fallopian Tubes. Nature 168, no. 4277 (1951): 697-8.
16 Edwards R. G., Steptoe P. C. A Matter of Life.
17 Там же.
18 Там же.
19 Там же.
20 Там же.
21 Recipient of the 20191ETS Pioneer Award: Dr. Barry Bavister. Reproduction, Fertility and Development 31, no. 3 (2019): vii – viii.
22 Там же.
23 Edwards R. G. et al. Early Stages of Fertilization In Vitro of Human Oocytes Matured In Vitro. Nature 221, no. 5181 (1969): 632-5.
24 Johnson M. H. Robert Edwards: The Path to IVF.
25 Johnson M. H. et al. Why the Medical Research Council Refused Robert Edwards and Patrick Steptoe Support for Research on Human Conception in 1971. Human Reproduction 25, no. 9 (2010): 2157-74.
26 Henig R. M. Pandora's Baby: How the First Test Tube Babies Sparked the Reproductive Revolution. Boston: Houghton Mifflin, 2004.
27 Hutchinson M. I Helped Deliver Louise. BBC News, 2003.
28 Там же.
29 Derbyshire V First IVF Birth: ‘It Makes Me Feel Really Special'. BBC News Two, 2015.
30 Nugent C. What It Was Like to Grow Up as the World's First ‘Test-Tube Baby'. Time, 2018.
31 Обложка журнала Time от 31 июля 1978:
http://content, time, com / time / magazine / o, 9263,7601780731, oo.html.
32 Derbyshire V First IVF Birth', см. также: Woo E. and Los Angeles Times. Lesley Brown, British Mother of First In Vitro Baby, Dies at 64. Health & Science. Washington Post, 2012.
33 Edwards R. G. Meiosis in Ovarian Oocytes of Adult Mammals. Nature 196 (1962): 446-50.
34 Adhikari D. et al. Inhibitory Phosphorylation of Cdki Mediates Prolonged Prophase I Arrest in Female Germ Cells and Is Essential for Female Reproductive Lifespan. Cell Research 26 (2016): 1212-25.
35 Conger K. Earlier, More Accurate Prediction of Embryo Survival Enabled by Research. Stanford Medicine News Center, 2010.
36 Там же.
1 Cohen J. The Untold Story of the ‘Circle of Trust' Behind the World's First Gene-Edited Baby. Asia/Pacific News. Science, 2019.
2 Там же.
3 Gardner R., Edwards R. Control of the Sex Ratio at Full Term in the Rabbit by Transferring Sexed Blastocysts. Nature 218 (1968): 346-8.
4 Там же.
5 Meyer L. et al. Early Protective Effect of CCR-3 Delta 32 Heterozygosity on HIV-i Disease Progression: Relationship with Viral Load. The SEROCO Study Group, AIDS, no. 11 (1997): F73-78.
6 28 Nov 2018— International Summit on Human Genome Editing. He J iankui presentation and QUA. YouTube, 1:04.28, WCSethics.
7 Belluck P. Gene-Edited Babies: What a Chinese Scientist Told an American Mentor. New York Times, 2019.
8 Cohen J. Untold Story of the ‘Circle of Trust. ’
9 Там же.
10 Lovell-Badge R. 28 Nov 2018— International Summit. YouTube.
11 Cyrano ski D. First CRISPR Babies: Six Questions That Remain. News, Nature, 2018.
12 Terry M. Reviewers of Chinese CRISPR Research: ‘Ludicrous’ and ‘Dubious at Best’. BioSpace, 2019.
13 Lovell-Badge R. 28 Nov 2018 – International Summit. YouTube; см. также: Second International Summit on Human Genome Editing: Continuing the Global Discussion, November, 2.7-29, University of Hong Kong, China. Washington, DC: National Academies Press, 2018.
14 Cohen J. Untold Story of the ‘Circle of Trust.’
15 Cyranoski D. CRISPR-baby Scientist Fails to Satisfy Critics. News, Nature, 2018.
16 Cyranoski D. Russian ‘CRISPR baby’ Scientist Has Started Editing Genes in Human Eggs with Goal of Altering Deaf Gene. News, Nature, 2019.
17 Из беседы с Ником Лейном в январе 2022 года.
18 Pennisi Е. The Power of Many.
19 Grosberg R. K., Strathmann R. R. The Evolution ofMul-ticellularity: A Minor Major Transition? Annual Review of Ecology, Evolution, and Systematics 38 (2007): 621-54.
20 Там же.
21 Ratcliff W C. et al. Experimental Evolution of Multicellularity. PNAS 109, no. 5 (2012): 1595-600.
22 Из беседы с Уильямом Рэтклифом в декабре 2021 года.
23 Там же.
24 Pennisi Е. Evolutionary Time Travel. Science 334, no. 6058 (2011): 893-5.
25 Colizzi E. S. et al. Evolution of Multicellularity by Collective Integration of Spatial Information. eLife 9 (2020): 656349; см. также: Herron M. D. et al. De Novo Origins of Multicellularity in Response to Predation. Scientific Reports 9 (2019).
1 Wellmann J. The Form of Becoming: Embryology and the Epistemology of Rhythm, 1760–1830. New York: Zone Books, 2017.
2 Wolff C. F. Theoria Generationis (dissertation). Halle: U H, 1759.
3 Goethe J. W. Letter to Frau von Stein, The Metamorphosis of Plants. Cambridge, MA: MIT Press, 2009.
4 Needham J. History of Embryology. Cambridge, UK: University of Cambridge Press, 1934. Подробно о развитии трофобласта: Knofler М. et al. Human Placenta and Trophoblast Development: Key Molecular Mechanisms and Model Systems. Cellular and Molecular Life Sciences 76, no. 18 (2019): 3479-96.
5 Thomas L. The Medusa and the Snail: More Notes of a Biology Watcher. New York: Penguin Books, 1995.
6 De Robertis E. M. Spemanns Organizer and Self-Regulation in Amphibian Embryos. Nature Reviews Molecular Cell Biology 7, no.
4 (2006): 296–302.
7 Gilbert S. F. Development Biology. Vol. 2. Sunderland, UK: Sinauer Associates, 2010; см. также: Harland R. Induction into the Hall of Fame: Tracing the Lineage of Spemanns Organizer. Development 135, no. 20 (2008): 3321-3, fig. 1; King R. C. et al. Heteroplastic Transplantation // A Dictionary of Genetics. New York: Oxford University Press, 2007; Hans Spemann, the Nobel Prize in Physiology or Medicine 1935. Nobelprize.org; Philbrick S., O’Neil E. Spemann-Mangold Organizer. The Embryo Project Encyclopedia, 2012; Spemann H., Mangold H. Induction of Embryonic Primordia by Implantation of Organizers from a Different Species. International Journal of Developmental Biology 45, no. 1 (2001): 13–38.
8 Thomas K. The Story of Thalidomide in the U. S., Told Through Documents. New York Times, 2020; см. также: Kim J. H., Scialli A. R. Thalidomide: The Tragedy of Birth Defects and the Effective Treatment of Disease. Toxicological Sciences 122, no. (2011): 1–6.
9 Interagency Coordination in Drug Research and Regulations. US Senate, 87th Congress. 93 (1961). (Письмо Фрэнсис Келси.)
10 Там же.
11 Thomas К. The Story of Thalidomide in the U. S.
12 Там же.
13 Asatsuma-Okumura T. et al. Molecular Mechanisms of the Teratogenic Effects of Thalidomide. Pharmaceuticals 13, no. 5 (2020): 95.
14 McFadden R. D. Frances Oldham Kelsey, Who Saved U. S. Babies from Thalidomide, Dies at 101. New York Times, 2015.
Часть третья. Кровь
1 O’Malley М. A., Muller-Wille S. The Celias Nexus: Connections Between the History, Philosophy and Science of Cell Biology. Studies in History and Philosophy of Science Part C 41, no. 3 (2010): 169-71.
2 Virchow R. Letters of 1842, 26January 1843, Letters to his Parents, 1839 to 1864.